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surmount-5 tirzepatide versus semaglutide head-to-head nejm 2025 Tirzepatide (Zepbound; Eli Lilly and Co) demonstrated 47% greater relative weight loss compared to semaglutide (Wegovy; Novo Nordisk) in the SURMOUNT-5 phase 3b open-label trial. Full results will be presented at a

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