surpass-2 trial tirzepatide vs semaglutide weight loss Peptide Theory 🧬 | Tirzepatide produced almost 2x the weight loss of semaglutide in a head-to-head Phase 3 trial. In SURPASS-2 (Frías et al., NEJM 2021),
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SURMOUNT-1 (NEJM 2022) tested tirzepatide a dual GIP/GLP-1 receptor agonist in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants
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