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Tirzepatide vs Semaglutide for Obesity NEJM, May 2025 Relevant to endocrinology, internal medicine, cardiology, obesity medicine Tirzepatide: 20.2% weight loss at 72 wks Semaglutide: 13.7% Greater waist reduction

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Semaglutide vs Tirzepatide - what's the difference? Both are powerful GLP-1based medications that support weight loss and metabolic health, but they're not the same. Semaglutide (Ozempic/Wegovy) GLP-1 receptor agonist

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